The St Joseph Fire Department was dispatched to a structure fire in the 2700 block of Olive.
A number of fire crews are at the scene, currently working to put out that fire.
The fire was initially reported at 6:49am. Crews determined the power had already been shut off.
St Joseph police are directing traffic around the affected area. Crews at the scene reported one of the walls was buckling as they tried to put the fire out. They also reported the second floor had caved in.
A cloud of smoke from the fire was visible across a wide area of St Joseph.
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